Determination of the parathyroid hormone reference interval in patients with different stages of the chronic kidney disease

Secondary hyperparathyroidism (SHPT) is one of the most clinically significant complications chronic kidney disease (CKD) due to associated mineral, bone disorders, and metastatic calcification. The indicators mineral metabolism 635 patients with different CKD stages 50 persons control group were analyzed using a neural network algorithm mathematical technology BootStrаp, which allowed determining target PTH intervals for each stage in CKD, corresponding optimal density tissue, order improve survival this category patients. It was found that upper limit reference interval level GFR > 35 ml/min coincides general population, 15‒35 it 185 pg/ml, 3 times higher than < 15 500 pg/ml (7.5 population). In dialysis 500‒1500 possible maintain satisfactory parameters metabolism, >1500 determines extreme risk developing severe SHPT complications.